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On the one hand, TME immunomodulation can trigger macrophage polarization from alternately activated macrophages M2 to classically activated macrophages M1, offering intertumoral H 2 O 2 for the Fenton reaction (Zanganeh et al., 2016), which effectively generates ROS and triggers lipid peroxidation (Yang and Stockwell, 2016

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Crucially, the expression of lactate transporters varies between T cell subsets and is influenced by the immunological context, which underpins these divergent functional outcomes

Oxidative stress is thought to play a central role in the pathogenesis of these lung diseases

It has also been shown that kaempferol reduces diabetic neuropathy utilizing an oxidative effect [133]