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Thus, the regulatory effect of natural small molecule compounds on ferroptosis, especially on the treatment of kidney diseases, has attracted wide attention

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In addition, MLX transcription factors and LDs can bind to each other on the surface of LDs, which can alter the storage level of LDs in macrophages to meet the metabolic needs of cells in the current microenvironment (Mejhert et al., 2020)

However, in advanced HF, persistent AMPK activation has been associated with transcriptional suppression of CPT1, accelerating the decline in FAO capacity and reinforcing metabolic rigidity (Wang et al., 2009)