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This animal model study put an emergent need to complete GSH supplementation trial in MCI and AD patients for cognitive improvement as proposed earlier

10.1016/j.neuint.2009.05.001 Neurochem Int

These findings are consistent with the results obtained using neuron-astrocyte co-culture systems, which show that APOE4 mutations lead to impairment of neuronal LD synthesis, neuron-to-astrocyte LD transport, and the ability of astrocytes to degrade FA