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The alanine substitution of four key interacting residues at the self-association interface suppressed this aggregation, strongly supporting our hypothesis that the self-association interface is involved in the early stages of ApoE aggregation

PLoS One 9 , e103114, (2014)

The connection between splicing and cancer

Elevated alkaline phosphatase is associated with growth spurts, and it is expected that children in the study age range will normally have growth spurts