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It was found that vacation periods reversed hypomethylation accumulated during NSW, particularly in genes involved in glutamatergic neurotransmission and immune pathways, including CREB1, CAMK2B, and GRIN2C, highlighting the plasticity of epigenetic landscape in response to circadian stress and recovery 235

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For the 18 patients who are no longer eligible, we identified the reason evaluation was ended and how this was discovered in Table 1

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