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Lv W, Booz GW, Fan F, Wang Y, Roman RJ

The 5 non-coding region of HMOX1 includes regulatory sequences such as the heme response element, metal response element, hypoxia response element, heat shock response element, antioxidant response element, as well as binding sites for activator protein-1 and specificity protein-1

Furthermore, the primary isotope effect on the reaction kinetics was observed, which suggests the deprotonation of the -proton of hemithioacetal is the rate-determining step (Supplementary Fig

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When PhIP was mixed with pure 3-HPA not containing any acrolein at 4 C (temperature at which no acrolein formed, Table 2), no PhIP-M1 was detected (Fig