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10.1038/nrm3151 Nat

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While certain senolytic compounds have shown specificity for senescent cells in preclinical models, achieving this selectivity in humans remains a significant hurdle.120 For example, some senescence-associated proteins (eg, BCL-2, p53, SASP factors) are also expressed in normal, proliferating cells, leading to potential off-target effects.31 Therefore, optimizing senolytic agents to minimize side effects while maintaining efficacy is crucial

A non-compartmental model was used to compare all routes

Ingredients to Use at a Different Time: Strong Direct Acids (L-Ascorbic Acid, AHAs, BHAs): A highly acidic environment can potentially mess with the stability of peptides