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The intrinsic pathway is initiated by a change in mitochondrial membrane permeability, which not only activates caspase-9 and the downstream execution pathway via cytochrome C release, but also releases ROS

Pentadeca Arginate has been shown to significantly increase collagen synthesis, which is critical for tissue repair and regeneration

This activation reduces HO levels, increases CAT activity, and upregulates transcription of antioxidant genes, including HO-1, which help maintain redox homeostasis 17

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All testing was conducted during the animals light cycle