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Regulatory guidelines of the US food and drug administration and the european medicines agency for actively targeted nanomedicines, in Drug Delivery with Targeted Nanoparticles , eds

doi: 10.1111/j.1582-4934.2009.00926.x 161 GruenbacherGThurnherM

The first phase I clinical trial to study the toxicology, pharmacokinetics and biological effects of curcumin on human were conducted with 25 patients with high risk or pre-malignant lesions [407]