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PLoS One 10 (7), e0131464

Diverse Biological Activities The peptide's biological activities are remarkably diverse and include stimulation of collagen and glycosaminoglycan synthesis (critical for skin, connective tissue, and wound healing), activation of wound healing mechanisms, promotion of blood vessel formation (angiogenesis) to support tissue repair and regeneration, anti-inflammatory effects that resolve excessive inflammation while supporting beneficial healing responses, antioxidant and protective effects against oxidative damage and toxic compounds, attraction of immune and repair cells to sites of injury, remodeling of extracellular matrix through regulated metalloproteinase activity, stimulation of nerve outgrowth and regeneration, and even modulation of gene expression in patterns that reverse age-related changes and restore more youthful cellular function

Mordi RC, Ademosun OT, Ajanaku CO, Olanrewaju IO, Walton JC

Specification: State of solution: Clear and colorless Specific Rotation []D20: -15.5 to -17.5 Assay: 98.0% to 101.0% Loss on drying: 0.50% max. Chloride [Cl-]: 0.02% max. Ammonium [NH4]: 0.02% max. Sulfate [SO4]: 0.03% max. Impurities A.B.E. 0.5% max. Impurities C.D.. 1.0% max. Iron [Fe]: 10ppm max. Heavy metals [Pb]: 10ppm max. Arsenic [As2O3]: 2ppm max. Residue on ignition [sulfated]: 0.10% max

Safety and tolerability of multiple ascending doses of PRX002/RG7935, an anti--synuclein monoclonal antibody, in patients with Parkinson disease: a randomized clinical trial