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Numbing Cream (Optional/Recommended): For laser treatments or deeper peels, a topical numbing cream might be applied 20-30 minutes beforehand to enhance comfort

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It also oxidizes thiol groups of proteins, forming disulfide bonds that alter Bcl-2 family protein conformation and function, disrupting the balance between pro-apoptotic and anti-apoptotic proteins [79]

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It is known that some polymorphism of MTHFR would result in reduction of MTHFR enzyme activity as well as DNA methylation process, later shown to have significant impacts in various psychiatric diseases