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Heme: a versatile signaling molecule controlling the activities of diverse regulators ranging from transcription factors to MAP kinases

This is in line with the antigen-specificity of the response promoted by peptide immunotherapy, and resulted in the suppression by the pCons-induced T regs of the proliferation of CD4 + CD25 - T effectors cells and reduced production of proinflammatory cytokines

Epigenetic complexity in NRF2 regulation: While DNA methylation of the NRF2 promoter is well-characterized, the functional consequences of newly identified histone modifications and their crosstalk with long non-coding RNAs require further elucidation

Unfortunately, edaravone can only be used in a small subset of early-stage ALS patients (grade 1 or 2 in the Japan ALS Severity Classification, scoring at least 2 points on all 12 items of ALSFRS-R

Nat Rev Mol Cell Biol 25:424