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There, NFAT induces the transcription of essential immune cytokines, such as interleukin-2 (IL-2), to promote T-cell proliferation and immune response [46]

Mechanistically, this was found to be triggered by mTOR-mediated ROS production, which increased HIF1-mediated gene expression and in line with HIF1 known to drive glycolysis (Cheng et al., 2014) - upregulated glycolysis and a glycolytic flux towards lactate production (Sohrabi et al., 2018)

At higher doses, some individuals, particularly those predisposed to prolactin sensitivity, may experience symptoms including mood changes, sexual dysfunction, and in rare cases, mild gynecomastia

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Briefly, cells were washed with Hanks Buffered Salt Solution (HBSS) (Beyotime, China), then resuspended in DMEM containing 10 M H2DCFDA and 5 M MitoSOX