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Once successfully transported into the brain tissue, the newly synthesized glutathione helps clear neurotoxic metabolic byproducts and significantly reduces microglial activation, which is the primary driver of neuroinflammation

The resulting accumulation of acetaldehyde in tissues provokes an inflammatory response that manifests the unpleasant symptoms to discourage alcohol use 6

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Unlike macrophages that originate from hematopoietic stem cells in the bone marrow, microglia arise from precursors within the CNS during embryonic development

8,9 In numerous rat models, hemin, the HO-1 enhancer, has been shown to protect against oxidative and inflammatory tissue damage