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Dietary copper restriction in patients with hepatolenticular degeneration

Recent evidence shows that erastin, a canonical ferroptosis inducer, binds directly to VDAC2/3, disrupts mitochondrial iron homeostasis, and induces marked intramitochondrial iron accumulation

Increasing lipid peroxidation Redox balance with abundant GSH is important for the longevity of tumor cells

There has been extensive preclinical in vitro and in vivo research showing the relationship between metals such as copper, zinc, and iron and the onset and progression of neurodegenerative conditions such as Alzheimers disease

Manov I, Hirsh M, Iancu TC (2004) N-Acetylcysteine does not protect HepG2 cells against acetaminophen-induced apoptosis