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doi: 10.1080/15376510701623508 44

doi: 10.4161/cbt.11.8.15281 192

*** Director Cientfico, Ginecoobstetra, Instituto de Reproduccin Humana PROCREAR, Barranquilla, Colombia

23 Germline mutations and the subsequent second somatic mutation (also known as the two-hit model) caused by various environmental factors or exposure to high estrogenic factors lead to the accumulation of genomic changes