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In order to reduce systemic and hepatic inflammation, the intervention inhibited NF-B signaling, which decreased the hepatic expression of pro-inflammatory cytokines such as TNF- , IL-6, and MCP-1

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The proportion of RBD species (dimer and monomer) was measured in the elution of the cation exchange chromatography immediately before the final size exclusion chromatography step (Supplementary Figure S6)