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Corticosteroids, methotrexate, biologics like infliximab and adalimumab, they all work by dampening immune activity across the board

Clin Nutr (2021) 40:464452

Morgulis, A., Gertz, E.M., Schffer, A.A

However, there is no scientific evidence supporting B12 supplementation for direct fat loss in individuals with normal B12 levels

Transforming growth factor-beta (TGF-) is a pleiotropic cytokine that regulates various cellular processes, including cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling [20]