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Biometals 25 , 677686 (2012)

It is one of the most powerful antioxidants produced by the body itself

For instance, the active exclusion of Ca 2+ from the cytosol is impaired, 43 and the resulting increase in cytosolic Ca 2+ induces its uptake by mitochondria, leading to mitochondrial dysfunction and the opening of the mitochondrial permeability transition pore (MPTP)as a cause of cell death

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revealed that the ratio of HDL to TC was reduced in individuals with MDD, suggesting that MDD may be associated with impaired RCT function and an elevated risk of atherosclerosis (131)