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119(5 Suppl 1): S10S16

Figure 5 A pivotal finding highlighted in this review is the initiation of a multi-faceted pathological cascade in the testicular microenvironment by varicocele-induced venous congestion: elevated local temperature, hypoxia, and metabolic waste accumulation trigger immune cell infiltration and activation, leading to the overproduction of pro-inflammatory cytokines (TNF-, IL-1, IL-6) and ROS