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Major limitations include difficulties in maintaining the complex three-dimensional architecture of seminiferous tubules, establishing appropriate hormonal microenvironments, and sustaining long-term culture conditions necessary for the extended timeline of human spermatogenesis

For animals with chronic conditions or ongoing nutritional requirements, it may be given periodically, such as once every two to four weeks

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Most common are gastrointestinal side effects, including diarrhoea, vomiting, nausea and abdominal pain