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TSPO interacts with VDAC1 and triggers a ROS-mediated inhibition of mitochondrial quality control Autophagyin press)

The difference is that while cholera enterotoxin causes pathologic changes in intestinal permeability, larazotide improves intestinal permeability and helps to reduce the immune response that occurs when the intestinal membrane is too permeable causing small molecules such as gluten to cross the protective membrane into the blood stream increased membrane permeability or hyperpermeability of the intestinal membrane

Any disruption in this pathway due to low stomach acid, gut issues, or dietary restrictions can impact B12 status

(2022) Med Sci Sports Exerc, 54: 417