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Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

Conclusion Your liver works harder than any other organ in your body, processing everything from your morning coffee to environmental toxins

This reveals a critical principle: for predicting the clinical outcome of protein-binding drug interactions, understanding the drug's extraction ratio is more important than simply knowing its degree of protein binding

Divided into three groups, participants received oral supplementation of GSH (250 mg/d), GSSG (250 mg/d), or a placebo for 12 weeks

Specifically, lysine lactoylation was decreased in HF-SAAR WT mice compared to WT HF-CTRL (Fig