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aCSF was removed by careful suctioning and replaced with aCSF containing vehicle (aCSF + aCSF), 100 ng/ml with carrier free adult recombinant Hepatocyte Growth Factor (HGF) (R and D Systems, MN, USA) in aCSF, 10 "10 M Hinge (Harding lab), 50 ng/ml in aCSF, 10 "10 M Dihexa (Harding lab) in aCSF, 10 "12 M Dihexa in aCSF or 50 ng/ml HGF + 10 " ' 2 M Dihexa in aCSF for 30 minutes at 37C with gentle rocking

Future research will need to clarify the extent to which these mechanisms are translatable into clinical practice and what their long-term implications may be for the human population

Changes of cell membrane potential in HCMECs

In medicine, synthetic peptides have been studied for decades

Compatibility of the additive with the oligomers and reactive diluents is indispensable for its efficiency