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Perhaps have a read of this: pernicious-anaemia-society

Semaglutide works by slowing gastric emptying and altering central appetite signaling through GLP-1 receptor activation

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Any weight change tracks the programme, over weeks to months

Therefore, structurally modified analogues with an altered OXM pharmacological profile have been produced with longer duration of action, good safety profile, and positive effects on body weight (and glucose metabolism) management in animal studies (143)