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Mutations in this domain have been associated with severe hemolytic conditions requiring chronic transfusion support (Reisz et al., 2018)

The regulation of lipid metabolism is critical for immune cell function and response), and amino acid metabolism (certain amino acids, such as glutamate, arginine, cysteine, etc., play important roles in anti-tumor, anti-aging, antioxidant, and anti-infection responses) 1,2,3,4

OXM reduced nutrient intake (35% 9%) resulting in significant weight loss compared to placebo (2.3 0.4 kg vs 0.5 0.5 kg, respectively)

This is particularly relevant in the context of BH3 mimetics, as they display limited anticancer activity when used in monotherapy settings 81

Effects of Novel Dual GIP and GLP-1 Receptor Agonist Tirzepatide on Biomarkers of Nonalcoholic Steatohepatitis in Patients With Type 2 Diabetes