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This NFE2L2 genetic baseline is the transcriptional layer above all the individual enzyme variants described above: it sets the stress-responsive amplification capacity of the entire glutathione synthesis, recycling, and deployment network

Such studies could advance our understanding of the molecular mechanisms underlying GR homeostasis dysregulation in various pregnancy disorders and lead to novel strategies to prevent or reverse these molecular changes, ultimately paving the way for optimized perinatal glucocorticoid therapies in the era of precision medicine

Cheff DM, Cheng Q, Guo H, Travers J, Klumpp-Thomas C, Shen M, et al

L., Sandler, D

The cochlear CRF signaling systems and their mechanisms of action in modulating cochlear sensitivity and protection against trauma