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Reduced autophagic flux can lead to dysfunctional organelle accumulation, increasing oxidative stress and ferroptotic sensitivity (79)

When autophagy is initiated, an isolated membrane structure called a phagophore is formed at a special region associated with the endoplasmic reticulum (ER), Golgi apparatus, and ERGolgi intermediate compartment 20,21,22

emerging evidence suggests that women may experience stronger melatonin suppression and phase-shifting responses than man under 400-2000 lux lighting (58, 59)