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While direct drug interactions are unlikely based on known mechanisms, the lack of safety studies and standardized formulations means healthcare providers cannot definitively assess safety or benefit

In the most recent clinical trials, less than 5% of people discontinued GLP-1 medications because of side effects

doi:10.1007/s10517-016-3370-x

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METAOD002: A Phase IIa (double-blind, placebo-controlled 4 4 Latin Square design) safety study with single doses (25, 50 and 100 g/kg AOD9604) administered intravenously to 23 healthy clinically obese males presenting with a BMI 35 kg/m 2