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This peptide has shown remarkable abilities in promoting the integrity of the stomach mucosa, continuously presenting cytoprotective agents that help counteract lesions in the gastrointestinal tract and other organs

246 For example, SMAD2 ubiquitination by Itch/AIP4 promotes its phosphorylation by TRI, facilitating signal transduction

-Tocopherol (30 mg/kg, i.p.) has shown beneficial effects in experimental renal ischemia, including reduction in tubular damage scores and cast formation, decreased blood urea nitrogen (BUN) and creatinine elevations, protection against oxidative DNA damage in renal tubular cells, and preservation of glomerular filtration capacity [53]

Comet Assay for DNA damage The Comet Assay Kit (Trevigen, Gaithersburg, MD) was used to detect single- and double-stranded DNA breaks in cultured cells

E., Hibino, T