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In general, the protective mechanism of L-theanine for the liver and kidney is to inhibit the NF-B pathway, regulate pro-inflammatory cytokines, such as IL-1, IL-6, IL-10, and TNF, and finally regulate the activities of AST, ALT, T-SOD, and other related enzymes, to effectively protect the liver and kidney and deal with liver and kidney injury caused by different reasons

For example, Papokastas and colleagues 5 found that treatment of major depressive disorder (MDD) with 15mg of Lmethylfolate in conjunction with an SSRI showed significantly greater efficacy compared to SSRI therapy alone regarding response rate and degree of change in depression symptom scores

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[DOI] [PMC free article] [PubMed] [Google Scholar] 106.Fasano, C., Disciglio, V., Bertora, S., Lepore Signorile, M

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