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Instead, activation energy barriers largely prevent their interaction and, thus, the approach to equilibrium (Floh, Enzyme-based redox signaling Signaling requires the reversible modification of a sensor and the subsequent activation of transducer and effector molecules (Figure 1)

By acting as electron donors, these compounds can reduce Fe 3+ to Fe 2+ , enhancing the cell redox buffering capacity

10.1016/j.bmcl.2015.07.018 121 LeeJ.KangE

Experimental treatments utilizing rapamycin, which activates autophagy, are under investigation to determine their potential to reduce atherosclerotic plaque burden in patients with cardiovascular disease [149]

However, a few important questions remain to be answered for the effective clinical application of ferroptosis-focused treatments