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Further delineation of underlying mechanisms driving CRPC led to the finding that CRPC is not androgen independent, but continues to rely on androgen and AR activity

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In parasites at 42 hpi, 3-h DFO treatment affected symbiont-containing vacuole formation and extracellular organelle function, while 3-h DHA treatment influenced symbiont entry into the host, protein binding, and rhoptry/apical complex functions, consistent with the effects of 9-h DFO and DHA treatments, which additionally involved the actin cytoskeleton and extracellular membranes