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(117) confirmed that IS severely accumulates in patients with end-stage renal disease (ESRD), accompanied by significant expansion of indole-producing bacteria and upregulation of bacterial tryptophan metabolic pathways

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post-parturient hemoglobinuria in cattle, dogs and cats with diabetes mellitus treated with insulin), osmotic lysis (water or hypotonic fluid), DMSO (very high doses [Appell et al 1992), acute liver failure (horses, unknown mechanism [Ramaiah et al 2003]), and envenomation (spiders, snakes [Dickinson et al 1996, Willey and Schaer 2002, Pagano et al 2016], and bees [Noble and Armstrong 1999]) can all result in a hemolytic anemia, mostly due to extravascular hemolysis, although intravascular hemolysis has been reported after mass bee sting in a mare (Lewis and Racklyeft 2014)