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In addition, concomitant administration of FA (5 mg/day) with vitamin B12 (500 g/day) or FA (400 g/day) with metformin (1,700 mg/day) decreased HOMA-IR in patients with MetS and hyperinsulinemia [38], and elderly adults with vitamin B12 deficiency [40]

Commercial unfortified durum wheat pasta lost 51% folate after boiling

Moreover, previous studies have demonstrated that AP-associated multi-organ dysfunction (e.g., lung, kidney, liver) can be improved by TCM prescription treatment, such as Dachengqi decoction (Liu et al., 2023), Yinchenhao decoction (Zhao et al., 2024), and Chaiqin Chengqi decoction (Yang X

It also causes metabolic disturbances, such as elevated lactate and reduced succinate and n-butyrate levels, aggravating gut microbiota imbalances 42