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The combination AZT plus indinavir induced an increase in ROS production, disruption in membrane mitochondrial potential, reduction in intracellular GSH levels, augment permeability of endothelial layer, leading cell death [49]

Elderly diabetes patients were older and complicated with a variety of chronic diseases, which was more likely to increase the risk of hypoglycemia caused by sulfonylureas (Sinclair et al., 2015)

259,260,261 By carefully selecting reaction conditions, catalysts, or chiral reagents, the selective synthesis of the desired stereochemical configuration of drug molecules can be achieved, thereby obtaining target compounds with specific stereochemical structures

Perspectives in in vitro models development Renal clearance is an important route of drug elimination from the bloodstream, mainly facilitated by the proximal tubule, which renders proximal tubule epithelial cells prone to drug-induced kidney injury

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