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doi: 10.3390/biomedicines8030050

Gluconeogenesis is an important process for maintaining glucose homeostasis under various conditions, and glutamine is a major gluconeogenic precursor[22]

123 Besides, oxidative stress conditions also increase the innately high IDH1 expression, and IDH1 silencing significantly enhances cell sensitivity to cancer chemotherapy, radiotherapy, and photodynamic therapy by reducing NADPH