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As mentioned, chronic kidney disease and dialysis can cause a variety of metabolic disorders, including disturbances of carnitine homeostasis [2,3]

Adverse effects were primarily mild gastrointestinal disturbances, similar to those in other KD studies

The Firmicutes/Bacteroidetes ratio: a relevant marker of gut dysbiosis in obese patients

and (4) LC chelated with metal ions by forming complexes with lysine and methionine amino acids, which are precursors for the first biosynthetic step of LC, while metal ions directly affect LC transfer via inhibition of carnitine acetyltransferase enzymatic activity (mitochondria) or indirectly by mediating organic cation transporter 2 activity (gut absorption) (Tjale et al