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Histamines and antihistamines: histamine and derivative thereof (betazole), antihistamines (Hl-antagonists, H2-antagonists), histamine metabolism drugs, agents as disclosed in U

By employing physical encapsulation or chemical conjugation, these platforms circumvent the physicochemical limitations inherent to many PROTACs, thereby liberating medicinal chemistry efforts from the empirical correction of poor drug-like properties and enabling a sharper focus on optimizing the ternary complex for maximal degradation activity [56, 276,277,278]

Waiting for a single "definitive" large trial may mean missing years of potential benefit from an ingredient with a strong safety profile

M., Bassetto, C