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Consult a health-care practitioner for use beyond 6 months

N Engl J Med (2013) 368:157584

This leads to a long list of negative effects, such as: tears and scarring, weak spots that rupture easily, blood clots, increased plaque buildup, and increased workload on the heart

Berberine should be avoided during pregnancy and breastfeeding due to potential risks to the infant, including concerns about effects on bilirubin metabolism in newborns