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Contraindications GHK-Cu peptide therapy may not be suitable for individuals who: Have known hypersensitivity to copper peptides Are pregnant or breastfeeding without medical clearance Have active skin infections at the application or injection site A consultation is required to determine suitability

The peptide's antioxidant mechanism operates through activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, a master regulator of cellular antioxidant responses

And it delivers copper to enzymes called lysyl oxidase and lysyl hydroxylase, which are responsible for cross-linking collagen fibers into strong, stable structures

The cultures were maintained in 35-mm polystyrene culture dishes at 37C within a humidified atmosphere containing 5% CO to mimic physiological conditions [1]