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For injectable routes, beyond localized reactions like pain or swelling at the injection site, observing for systemic effects becomes paramount

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However, treatments with GABA, DSIP-CBBBP, and DSIP all resulted in increased struggle times compared to the model group, with CBBBP alone not showing a similar effect, indicating a differential impact on depressive-like behaviors and highlighting the potential therapeutic value of these treatments in addressing depressive symptoms associated with insomnia (Riemann et al., 2020

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