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But caloric restriction, combined with the reduced nutrient density of a smaller total food volume, creates conditions where B vitamins including B12 become limiting factors for mitochondrial energy production

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It is estimated that 200 mg/kg is lethal to humans, based on the observation that 12 g caused the death of a woman weighing about 60 kg (Alexeef et al., 1990)

Oxidative stress induced by optic nerve injury contributes to inflammation and activation of M1-type microglia/macrophages, preventing axon regeneration [121]

Detailed mechanistic investigations show that the cleavage of the selenoethyl arm proceeds through an anionic mechanism with assistance of the cysteine thiol group