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Advancements in nucleic acid chemistry have considerably improved drug stability and pharmacokinetics, offering more effective long-term treatment options for reducing the incidence and mortality of CVDs

Interactions between GSH and OH resulted in the abstraction of the thiol H-atom, leading to the formation of a water molecule and a glutathione radical (GS), located on the cysteine

10.1097/GIM.0b013e3181614289 34

504 Besides, the disulfide bridge cleavage induced by intracellular glutathione (GSH) in lysosomes facilitated the disassembly of LNPs and the release of the encapsulated RNA molecules

Neuron 75 , 618632 (2012)