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Notably, several proline residues of EPOP, including P320, P322, and P323 from L1, and P335 from H, jointly contribute to the critical shape complementarity of the binding interface (Fig

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[5] Figure 1, demonstrates how histidine is metabolised into histamine, in which it is broken down via two pathways using the enzyme diamine oxidase (DAO) and or histamine- N -methyltransferase (HNMT)

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Further investigation showed that CPs first reduce the level of skin oxidation, inhibit the expression of the key transcription factor AP-1 (c-Jun and c-Fos), then activate the TGF-/Smad signaling pathway to promote collagen synthesis, inhibit the expression of MMP-1/3 to inhibit collagen degradation, and inhibit skin inflammation to alleviate skin aging in mice