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Although clinical symptoms should receive more weight in diagnosing B12 deficiency, the panelists recognized the need to use serum vitamin B12 concentrations as a cost-effective screening marker and the need to additionally measure a metabolic marker to support the diagnosis

But if left untreated, it may cause the following symptoms: Weakness, tiredness, or lightheadedness Lack of energy A decline in your mental abilities, such as memory and focus A painful and red tongue (glossitis) Mouth ulcers Pins and needles (paraesthesia) Disturbed vision Irritability Causes of Vitamin B12 deficiency

Leukemia 35:562572 Martin T, Shah N, Richter J, Vesole D, Wong S, Huang C et al (2021) Phase 1b trial of isatuximab, an anti-CD38 monoclonal antibody, in combination with carfilzomib as treatment of relapsed/refractory multiple myeloma

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