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PMID: 10543018

So like whatever it is because the mitochondria are for the most part, not as active in the cancer cell

Our mechanistic investigations revealed that selenomethionine serves as a selenium donor for GPX4 biosynthesis beyond the transsulfuration pathway

The ability to sustain synthesis activity in this context relies in part on diverse protein complexes of NHEJ core factors that bridge the two ends together, effectively acting as a surrogate for an intact template strand (Fig