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10.1021/jo0100906 66 JenC

This senescence-associated secretory phenotype is a result of the extrusion of cytoplasmic chromatin fragments in senescent cells, which act on the DNA sensing and effector cGAS-STING pathway to drive expression of interferon and NF-kB elements (Dou et al., 2017

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The study revealed that TCW effectively mitigated pro-inflammatory gene expression and attenuated hepatocyte damage associated with increased inflammatory cytokines and enhanced nitric oxide synthesis