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Ann New York Acad Sci , 2010, 1207: 4649 Acknowledgements This work was supported by the National Natural Science Foundation of China (82241058, U20A20259), the Program of Tianjin Municipal Science and Technology (21JCZDJC00290), the Natural Science Foundation of Tianjin of China (22JCYBJC00980), the Fundamental Research Funds for the Central Universities, the Natural Science Foundation of Hebei Province (B2020201092, B2023201108, 2567635H), the Foundation of Hebei Education Department (JZX2024018) and the Advanced Talents Incubation Program of Hebei University (521100223250)

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1056,1057 Alpha-tocopheryl succinate (-TOS) inhibits complex II, inducing cytotoxicity in tumor cells by promoting electron leakage and ROS generation