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SUSTAIN 9: Ozempic injection as an add-on to SGLT-2i MET/SU 6 Study design: 30-week, multinational, randomized, double-blind, parallel-group, placebo-controlled trial evaluating the efficacy and safety of adding Ozempic injection 1 mg to SGLT-2i metformin/sulfonylurea vs SGLT-2i + placebo metformin/sulfonylurea

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Standard Dosing Parameters Primary Application Dosing 1-2 mg daily 2-3 mg daily or 2 mg 2-3x per week 1-2 mg daily (injectable or topical) 2-5 mg daily under medical supervision Clinical studies used 0.3 mg/mL injections, while systemic wound healing in animal studies used approximately 1.1 mg/kg body weight (translating to ~75 mg total for humans in divided doses)

Ozempic Common Side Effects Nausea, vomiting, diarrhea, stomach (abdominal) pain, and constipation [8] Serious Side Effects Thyroid tumor/cancer, pancreatitis, gallbladder problems, low blood sugar, kidney problems, changes in vision, or allergic reactions [8] Reybelsus Common Side Effects Nausea, stomach (abdominal) pain, diarrhea, decreased appetite, vomiting, and constipation [9] Serious Side Effects Thyroid tumor/cancer, pancreatitis, gallbladder problems, low blood sugar, kidney problems, changes in vision, or allergic reactions [9] Wegovy Common Side Effects Nausea, diarrhea, vomiting, constipation, stomach (abdominal) pain, headache, tiredness (fatigue), upset stomach, dizziness, feeling bloated, belching, low blood sugar in people with type 2 diabetes, gas, stomach flu, heartburn, and runny nose or sore throat [10] Serious Side Effects Thyroid tumor/cancer, pancreatitis, gallbladder problems, low blood sugar, kidney problems, changes in vision, allergic reactions, increased heart rate, depression, or thoughts of suicide [10] How much does Ozempic cost